Local / topical

Pepper cream, cayenne cream.

Curcuma / turmeric essential oil in Dosoky et al. 2018

Nigella oil See reference in Oral

Oral

Astragalus mongholicus = Mongolian milkvetch
+ Cinnamomum cassia = Chinese cassia = Cassia cinnamon = Chinese cinnamon in Jo et al. 2023

Nigella = devil-in-a-bush = love-in-a-mist = black cumin in Hannan et al. 2021 ; Khodaie et al. 2024

Salvia officinalis L. = sage in Oveissi et al. 2019

Liquorice = Glycyrrhiza glabra Jeong et al. 2015
About blood pressure : each and every human has a very different way to assimilate liquorice.
10 g per day should be safe but, as the aim is to cure with liquorice, the amount should be augmented !!!
Measuring blood pressure is the right way to make sure not to be hypersensitive.

Mitochondria damage therapy

For any disease, it is reasonable to assume that the mitochondria of each cell have been affected.
So, helping mitochondria is a good idea.
Sprirulina Machihara et al.2023

Ubiquinol Kaneka + lipoïc acid + gluthatione.

A good Multivitamin + multimineral formula.

Always suspect the whole spectrum of possible imbalance

Up : Kelly Turner’s survivors 9 points to improve

References

Dosoky, N.S. and W.N. Setzer. Chemical composition and biological activities of essential oils of curcuma species. Nutrients. 2018;10(9). doi: 10.3390/nu10091196. PubMed PMID:30200410; PMCID: PMC6164907.

Hannan, M.A., M.A. Rahman, A.A.M. Sohag, M.J. Uddin, R. Dash, M.H. Sikder, M.S. Rahman, B. Timalsina, Y.A. Munni, P.P. Sarker, M. Alam, M. Mohibbullah, M.N. Haque, I. Jahan, M.T. Hossain, T. Afrin, M.M. Rahman, M. Tahjib-Ul-Arif, S. Mitra, D.F. Oktaviani, M.K. Khan, H.J. Choi, I.S. Moon, and B. Kim. Black Cumin (Nigella sativa L.): A Comprehensive Review on Phytochemistry, Health Benefits, Molecular Pharmacology, and Safety. Nutrients. 2021;13(6). doi: 10.3390/nu13061784. PubMed PMID:34073784; PMCID: PMC8225153.

Jeong, S.-J., H.-S. Lim, C.-S. Seo, J.-H. Kim, S.-E. Jin, S.-R. Yoo, and H.-K. Shin. Traditional herbal formula Jakyakgamcho-tang (Paeonia lactiflora and Glycyrrhiza uralensis) impairs inflammatory chemokine production by inhibiting activation of STAT1 and NF-κB in HaCaT cells. Phytomedicine: International Journal of Phytotherapy and Phytopharmacology. 2015;22(2):326–332. doi: 10.1016/j.phymed.2014.12.002. PubMed PMID: 25765840.

Jo, H.-G., E. Baek, and D. Lee. Comparative Efficacy of East Asian Herbal Formulae Containing Astragali Radix-Cinnamomi Ramulus Herb-Pair against Diabetic Peripheral Neuropathy and Mechanism Prediction: A Bayesian Network Meta-Analysis Integrated with Network Pharmacology. Pharmaceutics. 2023;15(5). doi: 10.3390/pharmaceutics15051361. PubMed PMID:37242603; PMCID: PMC10221388.

Khodaie, S.-A., R. Razavi, H. Nikkhah, N. Namiranian, and M. Kamalinejad. Nigella sativa L. and its bioactive and nutraceutical components in the management of diabetic peripheral neuropathy. Inflammopharmacology. 2024;32(5):2897–2920. doi: 10.1007/s10787-024-01528-6. PubMed PMID: 39143432.

Machihara, K., S. Oki, Y. Maejima, S. Kageyama, A. Onda, Y. Koseki, Y. Imai, and T. Namba. Restoration of mitochondrial function by Spirulina polysaccharide via upregulated SOD2 in aging fibroblasts. iScience. 2023;26(7):107113. doi: 10.1016/j.isci.2023.107113. PubMed PMID:37416477; PMCID: PMC10319841.

Oveissi, V., M. Ram, R. Bahramsoltani, F. Ebrahimi, R. Rahimi, R. Naseri, T. Belwal, H.P. Devkota, Z. Abbasabadi, and M.H. Farzaei. Medicinal plants and their isolated phytochemicals for the management of chemotherapy-induced neuropathy: therapeutic targets and clinical perspective. Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences. 2019;27(1):389–406. doi: 10.1007/s40199-019-00255-6. PubMed PMID:30852764; PMCID: PMC6593128.

Illustration

Picture of the day on WikiMedia Charles Sharp